| abstract |
A composition comprising an isomeric mixture of a modified cyclosporine analog on amino acid residue 1 with a 1,3-diene substituent, wherein the isomeric mixture comprises 75% to 95% by weight of the E-isomer and 25% to 5% by weight of the Z isomer, so that the sum of the percentage by weight of the isomer (E) and the isomer (Z) is 100 percent by weight, wherein the isomers are the E and Z isomers specified below: (See formula) |