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publicationDate 2009-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2310504-T1
titleOfInvention PROCEDURE FOR THE PREPARATION OF MEMANTINE CHLORHYDRATE SUBSTANTIALLY FREE OF IMPURITIES.
abstract Method for the preparation of memantine HCl having less than about 0.15% of one or both of between Ac-NH-TMAD and Ac-NH-MMAD comprising the measurement of an amount of at least one or both of N -acetyl-1-amino-3,5,7-trimethylamantane (Ac-NH-TMAD) and N-acetyl-1-amino-3-methylamantane (Ac-NH-MMAD) in a batch of 1-acetamido-3, 5-dimethylamatane, the selection of a batch of 1-acetamido-3,5-dimethylamantane having less than about 0.15% of one or both of Ac-NH-TMAD or Ac-NH-MMAD and the transformation of the selected batch of 1-acetamido-3,5-dimethylamantane in memantine HCl containing less than about 0.15% of at least one of DesMe-MMN HCl or MeMMN HCl.
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