| abstract |
A compound represented by the following formula (I), or a salt thereof or a hydrate thereof: (See formula) in which X is a cyclic group of imidazo [1,2-a] pyridine and has (R 4) n as substituent groups in which n is 0, 1, 2 or 3, and the substituent groups (R 4) n independently represent a hydrogen atom, halogen atom, cyano group, hydroxyl group, amino group, C1-alkyl group 6, halogenated C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkylsulfonyl group, C1-6 alkylsulfonylamino group, C1-6 alkylsulfinyl group, N- (C1-6 alkyl) amino group, N, N-di group (C1-6 alkyl) amino, C1-6 alkoxy group, C1-6 alkylsulfanyl group, carbamoyl group, N- (C1-6 alkyl) carbamoyl group, N, N-di (C1-6 alkyl) carbamoyl group, sulfamoyl group , phenyl group, heteroaryl group, phenoxy group, heteroaryloxy group, phenyl-C 1-6 alkylamino group or heteroaryl-C 1-6 alkylamino group, which is attached to an atom constituting X; Y is a phenyl group, pyridyl group, thienyl group, thiazolyl group, pyrazolyl group, 1,2,4-thiadiazolyl group, 1,2,4-oxadiazolyl group, 1,3,4-thiadiazolyl group, group 1,3, 4-oxadiazolyl or benzothiazolyl group; (Z) n are n groups (Z) attached to Y, in which n is 0, 1, 2 or 3, the Z groups are attached to an atom that constitutes the cyclic group Y and independently represent a group selected from (1 ) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9 ) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, ( 16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) formula -M 1 -M 2 -M 3, in which: M 1 and M 2 each represent a single bond, - (CH2) m-, -CHR 5 CHR 6 -, - (CH2) m-CR 5 R 6 - (CH2) n-, -CR 5 = CR 6 -, -C C-, -CR 5 = CR 6 - CO-, - (CH2) mO- (CH2) n-, -O- (CH2) n-CR 5 R 6 -, - (CH2) mS- (CH2) n-, -SO (CH2) m-, - SO2 (CH2) m-, -CO (CH2) m-, -COO-, -CONR 7 -, -CONR 7 CHR 8 -, -CONR 7 -CR 5 R 6 -, -CONR 7 - (CH2) m- , -NR 7 -, -NR 7 CO-CR 5 R 6 -, -NR 7 CO-CR 5 R 6 -CO-, -NR 7 CO- (CH2) m-, -NR 7 SO2 (CH2) m-, -SO2NR 7 - (CH2) m-, -SO2NR 7 - CR 5 R 6 -, -NR 7 CONR 8 - or -NR 7 CSNR 8 -, where n and m are independently 0, 1, 2 or 3, or (19) a group selected from (a) C6 - 14 aromatic hydrocarbon cyclic group , (b) C3-14 cycloalkyl group, (c) C4-14 cycloalkenyl group, (d) 5-14 membered aromatic heterocyclic group or (e) 4-14 membered non-aromatic heterocyclic group, each of which may being substituted with 4 or less groups selected from the substituent group Q, M 3 represents (i) hydrogen atom, (ii) oxo group, (iii) halogen atom, (iv) hydroxyl group, (v) amino group, (vi ) cyano group, (vii) nitro group, (viii) azido group, (viv) cyano group, (x) carboxyl group, (xi) C1-6 alkyl group, (xii) halogenated C1-6 alkyl group, (xiii) C1-6 alkyl group substituted with a hydroxyl or cyano group, (xiv) C2-6 alkenyl group, (xv) C2-6 alkynyl group, (xvi) alkenyl group Halogenated C2-6, (xvii) halogenated C1-6 alkoxy group, (xviii) -OR 7, (xviv) -NR 7 R 8, (xx) -NR 7 COR 8, (xxi) -COR 7, (xxii) -CONR 7 R 8, (xxiii) -SOR 7, (xxiv) -SO2R 7, (xxv) -NR 7 SO2R 8, (xxvi) -SO2NR 7 R 8, (xxvii) methylenedioxyl group, (xxviii) ethylenedioxyl group or (xxviv) (a) C3-8 cycloalkyl group, (b) C4-8 cycloalkenyl group, (c) 5 to 14 membered non-aromatic heterocyclic group, (d) C6-14 aromatic hydrocarbon cyclic group, (e) heterocyclic heterocyclic group 5 to 14 membered aromatic, (f) phenoxy group, (g) heteroalyloxy group or (h) C 3-8 cycloalkyloxy group, which may be substituted with 4 or less groups selected from substituent group Q; the substituent group Q represents an oxo group, halogen atom, hydroxyl group, amino group, cyano group, nitro group, azido group, cyano group, carboxyl group, C1-6 alkyl group, halogenated C1-6 alkyl group, C1 alkyl group - 6 substituted with a cyano or hydroxyl group, C2-6 alkenyl group, C2-6 alkynyl group, halogenated C2-6 alkenyl group, halogenated C1-6 alkoxy group, -OR 7, -OCH2CONR 7 R 8, -NR 7 R 8, -NR 7 COR 8, -COR 7, -CONR 7 R 8, -SOR 7, -SO2R 7, -NR 7 SO2R 8, -SO2NR 7 R 8, methylenedioxy group or ethylenedioxy group; R 1 represents ... |