http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2309962-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ddd5f458039b813e6ccbbaa3fc15666 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-33 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 |
| filingDate | 2006-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a88e1ef3bc2ee78242c86ac762958510 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff4c8f885d4f4565773d92300523e738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c883c1a523e3d20c20b2721b8d8cc61f |
| publicationDate | 2008-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2309962-T3 |
| titleOfInvention | IMPROVED METHOD FOR PREPARING GINKGO EXTRACTS THAT HAVE A REDUCED CONTENT OF POLYCYCLIC AROMATIC HYDROCARBONS. |
| abstract | Method for preparing an extract from Ginkgo biloba, which has a reduced content of polycyclic aromatic hydrocarbons, characterized in that (a) fresh or dried green leaves of Ginkgo biloba (drug) are extracted at a temperature of about 40 to 100 ° C, using with aqueous acetone, an aqueous alkanol having 1 to 3 carbon atoms, or anhydrous methanol, (b) the organic solvent is largely separated from the extract to a maximum content of 2% by weight, in which water can be added during the final distillation stages, (c) the remaining concentrated aqueous solution is diluted with water to a solids content of 5 to 25% by weight, cooled with stirring to a temperature below 6 ° C, allowed to stand for at minus 1 hour at this temperature, and the resulting precipitate, which consists of lipophilic components that are not very soluble in water, is removed, (d) ammonium sulfate is added to the remaining aqueous solution, and the solution The formed portion is extracted with methyl ethyl ketone or a mixture of methyl ethyl ketone and acetone, (e) the extract obtained is concentrated to a solids content of 50 to 70%, and the concentrate thus obtained is diluted with water and ethanol so that a solution containing 50% by weight of water and 50% by weight of ethanol at a solids content of about 10% by weight, filtration is carried out, and the filtrate is subsequently processed in (f), (f) an aqueous solution of a lead salt is added to the solution thus obtained until a color change from brown to amber occurs, and the precipitate formed is removed, or a polyamide is used instead of the lead salt, (g ) the remaining aqueous alcoholic solution is extracted with heptane in order to further remove the alkylphenolic compounds, (h) the remaining aqueous alcoholic solution is concentrated under reduced pressure to an ethanol content of about 5% by weight, and added with sulfate d and ammonium to a content of 20% by weight, (i) the solution obtained is extracted with a mixture of methyl ethyl ketone and ethanol, in a ratio of 8: 2 to 5: 5 (w / w), (k) the organic phase The resulting is dried with <_20% by weight of ammonium sulfate, and concentrated to a solids content of 50 to 70% by weight, added with ethanol so that an ethanol content of at least 80% by weight is obtained , it is maintained for at least 2 h <_12 ° C, and filtered, (l) the resulting filtrate is concentrated under reduced pressure to a maximum temperature of 60 to 80 ° C, and dried, thereby obtaining a dry extract having a content of water less than 5% by weight. |
| priorityDate | 2005-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.