abstract |
Compound of formula: (See formula) or a pharmaceutically acceptable salt thereof, in which Ar1 is (See formula) Ar2 is (See formula) X is O or S; R1 is -halo, -CH3, -C (halo) 3, -CH (halo) 2, or -CH2 (halo); each R2 is independently: (a) -halo, -NH2, -CN or -NO2; (b) -C1-C10 alkyl, -C2-C10-alkenyl, -C2-C10-alkynyl, -C3-C10-cycloalkyl, -C8-C14-cycloalkyl, -C8-C14-alkylcycloalkyl , -cycloalkenyl (C5-C10), -bicycloalkenyl (C8-C14), -trichloralkenyl (C8-C14), -heterocycle (3 to 7 members), or bicycloheterocycle (7 to 10 members), each of which is unsubstituted or substituted with one or more R5 groups; or (c) -phenyl, -naphthyl, -aryl (C14) or -heteroaryl (5 to 10 members), each of which is unsubstituted or substituted with one or more R6 groups; each R3 is independently: (a) -halo, -CN, -OH, -NO2, or -NH2; (b) -C1-C10 alkyl, -C2-C10-alkenyl, -C2-C10-alkynyl, -C3-C10-cycloalkyl, -C8-C14-cycloalkyl, -C8-C14-alkylcycloalkyl , -cycloalkenyl (C5-C10), -bicycloalkenyl (C8-C14), -trichloralkenyl (C8-C14), -heterocycle (3 to 7 members), or bicycloheterocycle (7 to 10 members), each of which is unsubstituted or substituted with one or more R5 groups; or (c) -phenyl, -naphthyl, -aryl (C14) or -heteroaryl (5 to 10 members), each of which is unsubstituted or substituted with one or more R6 groups; each R5 is independently -CN, -OH, -alkyl (C1-C6), -alkenyl (C2-C6), -halo, -N3, -NO2, -N (R7) 2, -CH = NR7, - NR7OH, -OR7, -COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, -SR7, -S (O) R7, or -S (O) 2R7; each R6 is independently -alkyl (C1-C6), -alkenyl (C2-C6), -alkynyl (C2-C6), -cycloalkyl (C3-C8), -cycloalkenyl (C5-C8), -phenyl, - heterocycle (3 to 5 members), -C (halo) 3, -CH (halo) 2, -CH2 (halo), -CN, -OH, -halo, -N3, -NO2, N (R7) 2, -CH = NR7, -NR7OH, -OR7, -COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, -SR7, -S (O) R7, or -S (O ) 2R7; each R7 is independently -H, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6-alkynyl, -C3-C8-cycloalkyl, (C5-C8) cycloalkenyl, - phenyl, -heterocycle (3 to 5 members), -C (halo) 3, -CH (halo) 2, or CH2 (halo); each R8 is independently -alkyl (C1-C6), -alkenyl (C2-C6), -alkynyl (C2-C6), -cycloalkyl (C3-C8), -cycloalkenyl (C5-C8), -phenyl, - C (halo) 3, -CH (halo) 2, -CH2 (halo), -CN, -OH, -halo, -N3, -NO2, -N (R7) 2, -CH = NR7, -NR7OH, - OR7, -COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, -SR7, -S (O) R7, or -S (O) 2R7; each R11 is independently -alkyl (C1-C6), -alkenyl (C2-C6), -alkynyl (C2-C6), -cycloalkyl (C3-C8), -cycloalkenyl (C5-C8), -phenyl, - C (halo) 3, -CH (halo) 2, -CH2 (halo), -CN, -OH, -halo, -N3, -NO2, -N (R7) 2, -CH = NR7, -NR7OH, - OR7, -COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, -SR7, -S (O) R7, or -S (O) 2R7; each halo is independently -F, -Cl, -Br, or -I; m is an integer between 0 and 4; or is an integer between 0 and 4; p is an integer between 0 and 2; q is an integer between 0 and 6; r is an integer between 0 and 5; and s is an integer between 0 and 4, wherein the compound is not N- (4-tert-butyl-phenyl) -4- (3-chloro-pyrazin-2-yl) -benzamide. |