http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2308868-B1

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filingDate 2005-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2009-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b158a020dcad756afe6c61691bc81f8
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publicationDate 2009-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2308868-B1
titleOfInvention USE OF ARRAYS OF SPECIFIC SEQUENCES OF HUMAN MITOCONDRIAL GENOME ON SOLID SUPPORT AND PROCEDURE FOR THE DETECTION OF MUTATIONS ASSOCIATED WITH THE OPTICAL NEUROPATHY OF LEBER.
abstract Use of specific sequence arrays ofnhuman mitochondrial genome on solid support and procedure fornthe detection of mutations associated with the Optic Neuropathy ofnLeber, using DNA chips. The procedure is based on thenamplification of fragments containing mutations andnpolymorphisms of interest and the determination of the base involved innthe same through a mini-sequencing reaction usingnprimers that at their end 5 'carry a tail (tag), for theirnsubsequent detection by hybridization of the products of thenmini-sequencing reaction with a microarray consisting ofncomplementary sequences to the tails (cTag).
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