| abstract |
Lentiviral packaging construction comprising a part of the pol lentiviral gene that includes the protease coding sequence and a deletion in the lentiviral packaging signal, wherein said protease coding sequence includes a mutation that results in a substitution of Thr to Ser in the coded lentiviral protease, said Thr to Ser substitution being the Thr residue in the Asp-Thr-Gly motif corresponding to amino acid number 26 of SEQ ID No. 1. |