| abstract |
Insulin precursor or insulin precursor analog comprising the formula: B (1-27) -X2-X3-X1Y-A (1--21) X1 is a peptide sequence of 1-15 amino acid residues one of which is an aromatic amino acid residue immediately N-terminal to Y, X 2 is Pro, Asp, Lys, or Ile at position 28 of the human insulin B chain, X3 is Pro, Lys, Ala, Arg or Pro-Thr in the position 29 of the human insulin B chain, Y is Lys or Arg, A (1-21) is the natural insulin A chain, and B (1-27) is the natural insulin B chain lacking B28 amino acid residues, B29 and B30. |