| abstract |
A compound according to the general Formula (I) (See formula) the pharmaceutically acceptable acidic or basic addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof, where: n is an integer, equal to 1; m is an integer, equal to 1; each R 1 independently of one another, is selected from the group Ar 1, Ar 1 -alkyl and di (Ar 1) -alkyl; R 4 is selected from the group of hydrogen, hydroxy and alkyloxy; Z is a bivalent radical - (CH2) r, where r is an integer equal to 1, 2, 3, 4 or 5 and where a radical -CH2- is optionally substituted by a radical> C = O; or R 4 and Z are taken together to form a trivalent radical = CH- (CH2) r - 1, where r is an integer equal to 1, 2, 3, 4 or 5 and where a radical -CH2- is optionally substituted by a radical> C = O; P is an integer equal to 1; Q is O or NR 3 X is a covalent bond or a bivalent radical of the formula -O-, -S- or NR 3 -; each R 3 independently of one or the other, is hydrogen or alkyl; R 2 is alkyl, Ar 2, Ar 2 -alkyl Het 1, Het 1 -alkyl, which is an integer, equal to 0 or 1; j is an integer, equal to 1; k is an integer, equal to 0 or 1; Y is a covalent bond or a bivalent radical of formula> C (= O) or -SO2-; each Alk represents ... |