| abstract |
CGRP antagonists of the general formula (See formula) in which they mean A an oxygen or sulfur atom, a phenylsulfonylamino or cyanimino group, X an oxygen or sulfur atom, an imino group, optionally substituted with a C1-6 alkyl group , or a methylene group, optionally substituted with a C1-6 alkyl group, or a C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl group, in which each methylene group may be substituted with up to 2 fluorine atoms and each methyl group may be substituted with up to 3 fluorine atoms, V a chlorine or bromine atom, an amino, methylamino or hydroxy group, W a hydrogen atom, fluorine, chlorine, bromine or iodine, a difluoromethyl or trifluoromethyl group, R 1 a heterocycle aza, diaza, triaza, oxaza, tiaza, tiadiaza or S, S-dioxide-thiadiaza of 5 to 7 members, saturated, unsaturated once or twice, the above-mentioned heterocycles being linked through a carbon atom or nitrogen, containing one or two carbonyl or thiocarbonyl groups adjacent to a nitrogen atom, one of the nitrogen atoms may be substituted with an alkyl group, and one or two carbon atoms may be substituted with an alkyl group, with a phenyl, phenylmethyl, naphthyl group , biophenyl, pyridinyl, diazinyl, furyl, thienyl, pyrrolyl, 1,3-oxazolyl, 1,3-thiazolyl, isoxazolyl, pyrazolyl, 1-methylpyrazolyl, imidazolyl or 1-methylimidazolyl, the substituents may be the same or different, and may be condensed an olefinic double bond of one of the above-mentioned unsaturated heterocycles with a phenyl, naphthyl, pyridine, diazine, 1,3-oxazole, thienyl, furan, thiazole, pyrrole, N-methylpyrrole or quinoline ring, with a 1H ring -quinolin-2-one, optionally substituted on the nitrogen atom with an alkyl group, or with an imidazole or N-methylimidazole ring, or also two olefinic double bonds of one of the unsaturated heterocycles precede They may be condensed in each case with a phenyl ring, where ... |