http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2306200-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f77f602782aff4a0a4afd4c9c474f99d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d77bf4c2727a530ee196b86b25d5518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a6abe9a8f1fa13e6c6bf485a790e35b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_874c6572b055ae72d78c92394c79d4bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22a847271158a426c4feaa48f281b382 |
| publicationDate | 2008-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2306200-T3 |
| titleOfInvention | BETA-SECRETASA MACROCICLIC INHIBITORS. |
| abstract | A compound having the structural formula: (See formula) or a pharmaceutically acceptable salt or solvate thereof, wherein: (See formula) R 1 is: R 2 is -N (R 5) C (O) R 4 - or a heterocyclylene ring; R 3 is arylene, heteroarylene, heterocyclylene or cycloalkylene; R 4 is arylene, heteroarylene, heterocyclylene or cycloalkylene; R 5 is hydrogen, alkyl, aryl, heteroaryl or cycloalkyl; R 6 and R 7 are independently selected from hydrogen, -OH, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, aralkoxy, heteroaralkoxy and alkoxy, with the proviso that when R 6 and R 7 are -OH , aralkoxy, heteroaralkoxy and alkoxy, R 6 and R 7 are not attached to a ring carbon adjacent to a ring nitrogen; R 8 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, -C (O) R 9, -C (O) OR 12, -S (O) R 9, -S ( O2) R 9 or -CN; with the proviso that when Y is = O, R 8 cannot be -C (O) R 9, -C (O) OR 12, -S (O) R 9, -S (O2) R 9 or -CN ; R 9 is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, alkenyl, alkynyl or -N (R 10) (R 11); R 10 and R 11 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl, aralkyl, heteroaralkyl, heterocyclylalkyl, alkenyl and alkynyl; or R 10 and R 11, together with the nitrogen to which they are attached, form a 3-7 membered heterocyclyl ring; R 12 is ... |
| priorityDate | 2004-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 288.