| abstract |
A substituted morpholine or thiomorpholine derivative of general formula I (See formula) in which: q is 0 or 1; W is O or S; X is CO; Z is O; R1 is selected from the group consisting of halogen, cyano, alkyl (en / in) C1-6 yl, cycloalkyl (en) C3-8yl, cycloalkyl (en) yl (C3-8) -alkyl (en / in) ilo (C1-6), halogen-alkyl (en / in) ilo C1-6, halogen-cycloalkyl (en) C3-8yl, halogen -cycloalkyl (en) yl (C3-8) -alkyl (en / in) ilo (C1-6), alkyl (en / in) C1-6 yloxy, C3-8 cycloalkyl (en) C3-8ylloxy (C3-8) -alkyl (C1-6) yl (en / in); R2 is selected from halogen, cyano, alkyl (en / in) ilo C1-6, cycloalkyl (en) ilo C3-8, cycloalkyl (en) yl (C3-8) -alkyl (en / in) ilo (C1-6 ), halogen-alkyl (en / in) C1-6 yl, halogen-cycloalkyl (en) ilo C3-8, halogen-cycloalkyl (en) yl (C3-8) -alkyl (en / in) yl (C1-6 ), alkyl (en / in) C1-6 yloxy, cycloalk (en) C3-8 yloxy and cycloalk (en) yl (C3-8) -alk (in / in) C1-6) yloxy, optionally substituted phenyl and optionally substituted pyridyl; wherein the phenyl and pyridyl are optionally substituted with one or more substituents that are independently halogen, C1-6 alkyl (en / in), C3-8 cycloalkyl or C3-8yl (en) yl (C3-8) -alk (en / in) yl (C1-6); R3 is cycloalk (en) yl (C3-8) -alk (en / in) yl (C1-6); each of R4, R5, R6 and R7 is independently selected from the group consisting of hydrogen and Ar; Ar is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted pyridine, optionally substituted thiophene, optionally substituted furan, optionally substituted thiazole, optionally substituted quinoline, optionally substituted indole, optionally substituted 2,3-dihydrobenzofuran, optionally substituted pyrimidine, optionally substituted pyrrole and optionally substituted oxazole; wherein the substituents are independently halogen, alkyl (en / in) C1-6 yl, cycloalkyl (en) C3-8yl, cycloalkyl (en) yl (C3-8) -alkyl (en / in) yl (C1- 6), halogen-alkyl (en / in) C1-6 yl, alkyl (en / in) C1-6 yloxy, alkyl (en / in) C3-8 yloxy; in the form of the free base or its salts. |