http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2303609-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac2c17e532220d91aca9a28ef60f178b |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
filingDate | 2003-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2008-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7e11f0c0dde89c48f7dbafd1e3a392a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f14cfbbf7c3af8fd931f646be33e2aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7742e171b942068ed1b8424436219136 |
publicationDate | 2008-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2303609-T3 |
titleOfInvention | BENZOAZOLILPIPERACINE DERIVATIVES THAT HAVE VR1 ANTAGONIST ACTIVITY. |
abstract | Compound of formula: (See formula) or a pharmaceutically acceptable salt thereof, where Ar1 is (See formula) A is (See formula) R1 is -Cl, -Br, -I, - (C1-C6) alkyl, -NO2 , -CN, -OH, -OCH3, -NH2, -C (halo) 3, -CH (halo) 2 or -CH2 (halo); each R2 is independently: (a) -halo, -CN, -OH, -O (C1-C6) alkyl, -NO2 or -NH2; (b) - (C1-C10) alkyl, - (C2-C10) alkenyl, - (C2-C10) alkynyl, - (C3-C10) cycloalkyl, - (C8-C14) bicycloalkyl, - (C8-C14) tricycloalkyl , - (C5-C10) cycloalkenyl, - (C8-C14) bicycloalkenyl, - (C8-C14) tricycloalkenyl, -heterocycle (3 to 7 members) or -bicycloheterocycle (7 to 10 members), each of which it is unsubstituted or substituted by one or more R5 groups; or (c) -phenyl, -naphthyl, - (C14) aryl or -heteroaryl (5 to 10 members), each of which is unsubstituted or substituted by one or more R6 groups; each R3 is independently: (a) -halo, -CN, -OH, -O (C1-C6) alkyl, -NO2 or -NH2; (b) - (C1-C10) alkyl, - (C2-C10) alkenyl, - (C2-C10) alkynyl, - (C3-C10) cycloalkyl, - (C8-C14) bicycloalkyl, - (C8-C14) tricycloalkyl , - (C5-C10) cycloalkenyl, - (C8-C14) bicycloalkenyl, - (C8-C14) tricycloalkenyl, -heterocycle (3 to 7 members) or -bicycloheterocycle (7 to 10 members), each of which it is unsubstituted or substituted by one or more R5 groups; or (c) -phenyl, -naphthyl, - (C14) aryl or -heteroaryl (5 to 10 members), each of which is unsubstituted or substituted by one or more R6 groups; R4 is -H or - (C1-C6) alkyl; each R5 is independently -CN, -OH, -halo, -N3, -NO2, -N (R7) 2, -CH = NR7, -NR7OH, -OR7, -COR7, -C (O) OR7, -OC ( O) R7, -OC (O) OR7, -SR7, -S (O) R7 or -S (O) 2R7; each R6 is independently - (C1-C6) alkyl, - (C2-C6) alkenyl, - (C2-C6) alkynyl, - (C3-C8) cycloalkyl, - (C5-C8) cycloalkenyl, -phenyl, - (C3 -C5) heterocycle, -C (halo) 3, -CH (halo) 2, -CH2 (halo), -CN, -OH, -halo, -N3, -NO2, -N (R7) 2, -CH = NR7, -NR7OH, -OR7, -COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, -SR7, -S (O) R7 or -S (O) 2R7; each R7 is independently -H, - (C1-C6) alkyl, - (C2-C6) alkenyl, - (C2-C6) alkynyl, - (C3-C8) cycloalkyl, - (C5-C8) cycloalkenyl, -phenyl, - (C3-C5) heterocycle, -C (halo) 3, -CH2 (halo) or -CH (halo) 2; R8 and R9 are each independently -H, - (C1-C6) alkyl, - (C2-C6) alkenyl, - (C2-C6) alkynyl, - (C3-C8) cycloalkyl, - (C5-C8) cycloalkenyl, -phenyl, -C (halo) 3, -CH (halo) 2, -CH2 (halo), -CN, -OH, -halo, -N3, -N (R7) 2, -CH = NR7, -NR7OH, -OR7, -COR7, -C (O) OR7, -OC (O) R7, -OC (O) OR7, -SR7, -S (O) R7 or -S (O) 2R7; each -halo is -F, -Cl, -Br or -I; n is an integer between 0 and 3; p is an integer between 0 and 2; m is 0 or 1; and x is 0 or 1. |
priorityDate | 2002-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1874.