| abstract |
A compound having the formula (I.1) or (II.1): (See formula) or a pharmaceutically acceptable salt or solvate thereof, wherein q = 0 or 1; R 1 is H, cycloalkyl, alkyl, R 23 -alkyl- or R 26; R a, R b and R c are, independently of each other, each H, alkyl, cycloalkyl, aryl, R 22 -aryl- or R 24 -alkyl-; or R a and R b together with the carbon to which they are attached, form a 4- to 7-membered ring, and R c is H or alkyl; (i) X is a link; Y is H, R 26, cycloalkyl, alkyl, R 25 -alkyl- or - (CH2) t TCOR 100, where t is 1 to 6, T is -O- or -NH-, and R 100 is H, R 26 , alkyl or R 26 -alkyl-; and R 2 is monohaloalkyl, polyhaloalkyl, with the proviso that it is not trifluoromethyl, azido, cyano, oximino, cycloalkenyl, heteroaryl, R 22 -heteroaryl- or R 27 -alkyl-; (ii) X is a link; Y is QV, where Q is a C1-C8 alkyl or bond, and V is: (a) aryl substituted with nitro, aminosulfonyl, cyano, monohaloalkyl, polyhaloalkyl, with the proviso that it is not trifluoromethyl, thiol, alkylthio, cycloalkyl, cycloalkylalkyl, -OCF3 or acyloxy, and optionally further substituted with 1 to 3 additional substituents independently selected from the group consisting of R 21; (b) R 22 -heteroaryl-; or (c) aryl or heteroaryl, each of which is independently substituted with 2 substituents on adjacent atoms of group V, which are joined to form a fused 4 to 8 non-aromatic carbocyclic or heterocyclic ring, and optionally further substituted with 1 or 2 additional substituents independently selected from the group consisting of R 21; and R 2 is H, halo, -CONHR 6, -CONR 6 R 7, -CO2R 6, monohaloalkyl, polyhaloalkyl, azido, cyano, -C = N-OR 6, cycloalkyl, cycloalkylalkyl, R 26, aminosulfonyl, alkyl or R 23 -alkyl-. |