| abstract |
New 4-benzylidenepiperidine derivatives of formula (I) (See formula) where X and Y independently represent a hydrogen or halogen atom, a hydroxyl, cyano, nitro, amino, alkylamino (C1-C4) group optionally substituted with one or more halogen atoms, arylamino optionally substituted with one or more halogen atoms, aralkylamino optionally substituted with one or more halogen atoms, C1-C4 alkylsulfonamido optionally substituted with one or more halogen atoms, optionally C1-C4 alkanoylamide substituted with one or more halogen atoms, an arylsulfonamido, alkylsulfonyloxy (C1-C4), carboxyl, trifluoromethyl, trifluoromethoxy, (C1-C4) -SO2-NH-CH2- alkyl, NH2- (CH2) 1-4-SO2 group -NH-, NH2- (CH2) 1-4- (CO) -NH-, sulfamoyl [NH2-SO2-], formyl [-CHO], aminomethyl [-CH2-NH2], hydroxymethyl, (C1-C4) alkyl , (C1-C4) alkoxy methyl, halomethyl, tetrazolyl, or (C1-C4) alkoxy, C1-C4 alkoxycarbonyl, (C1-C6) alkanoyloxy, phenyl or (C1-C4) alkoxy optionally Substituted with amino groups, or the adjacent X and Y groups, if necessary together with one or more identical or different additional heteroatoms and the groups -CH = and / or -CH2-, can form a homo- or heterocyclic ring of 4 -7 optionally substituted members, preferably a morpholine, pyrrole, pyrrolidine, oxo- or thioxopyrrolidine, pyrazole, pyrazolidine, imidazole, imidazolidine, oxo- or thioxoimidazole or imidazolidine, 1,4-oxazine, oxazol, oxazolidine, oxo- or thioxooxa, oxo- or thioxothiazolidine or 3-oxo-1,4-oxazine, Z is a hydrogen or halogen atom, a nitro, amino, (C1-C4) alkyl, (C1-C4) alkoxy, cyano, trifluoromethyl or trifluoromethoxy group ; optical enantiomers, racemates and salts thereof. |