http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2298782-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 |
| filingDate | 2004-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9ae529d15b964b9cc963a5d35c42c47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80553d14c3da98e91b35d063d5bdab09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1af0cef36da7e51f75b01ddbb20060b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f51cde2700649b231bd68423b3c082a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80890c07e7de4ba0de48acb8893ccbcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36326793f5cd2dd51343c4894ea847a1 |
| publicationDate | 2008-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2298782-T3 |
| titleOfInvention | 3-AMINOPIRROLIDINAS AS INHIBITORS OF MONOAMINE REABSORTION. |
| abstract | A compound of formula (I): (See formula) in which R 1 is C1-C6 alkyl (optionally substituted with 1, 2 or 3 halo substituents and / or with 1 substituent selected from -S- (C1-C3 alkyl) , -O- (C1-C3 alkyl) (optionally substituted with 1, 2 or 3 F atoms), -O- (C3-C6 cycloalkyl), -SO2- (C1-C3 alkyl), -CN, -COO- (C1-C2 alkyl) and -OH); C2-C6 alkenyl; (CH2) q-Ar2; or a group of formula (i) or (ii) (See formula) R 2, R 3 and R 4 each is independently selected from hydrogen or C 1 -C 2 alkyl; R 5, R 6, R 7 and R 8 each is independently selected from hydrogen or C1-C2 alkyl; -X- is a bond, -CH2-, -CH = CH-, -O-, -S-, or -SO2-; -Y- is a link, -CH2- or -O-; -Z is hydrogen, -OH or -O- (C1-C3 alkyl); p is 0, 1 or 2; q is 0, 1 or 2; r is 0 or 1; s is 0, 1, 2 or 3; t is 0, 1, 2, 3 or 4; Ar1 is selected from: (i) a phenyl group or a monocyclic heteroaromatic group of 5 or 6 members each of which is optionally substituted with 1, 2, 3, 4 or 5 substituents (depending on the number of positions of available substitution) each independently selected from halo, cyano, C1-C4 alkyl (optionally substituted with 1, 2 or 3 F atoms), -O- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 atoms of F) and -S- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 F atoms) and / or with 1 substituent selected from pyridinyl, pyrazolyl, phenyl (optionally substituted with 1, 2 or 3 halo substituents) , benzyl (optionally substituted with 1, 2 or 3 halo substituents) and phenoxy (optionally substituted with 1, 2 or 3 halo substituents) with the proviso that only C1-C4 alkyl can be a substituent for the H of any moiety -NH - present in a monocyclic heteroaromatic group of 5 or 6 members; or (ii) a naphthyl group or a bicyclic heteroaromatic group of 8, 9 or 10 members each of which is optionally substituted with 1, 2, 3, 4, 5 or 6 substituents (depending on the number of available substitution positions ) each independently selected from halo, cyano, C1-C4 alkyl (optionally substituted with 1, 2 or 3 F atoms), -O- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 F atoms) and -S- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 F atoms) with the proviso that only C1-C4 alkyl can be a substituent for the H of any moiety -NH- present in a group bicyclic heteroaromatic of 8, 9 or 10 members; and Ar2 is selected from (i) a phenyl group or a monocyclic heteroaromatic group of 5 or 6 members each of which is optionally substituted with 1, 2, 3, 4 or 5 substituents (depending on the number of available substitution positions ) each independently selected from halo, cyano, C1-C4 alkyl (optionally substituted with 1, 2 or 3 F atoms), -O- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 F atoms) and -S- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 F atoms) with the proviso that only C1-C4 alkyl can be a substituent for the H of any moiety -NH- present in a group 5 or 6 membered monocyclic heteroaromatic; or (ii) a naphthyl group or a bicyclic heteroaromatic group of 8, 9 or 10 members each of which is optionally substituted with 1, 2, 3, 4, 5 or 6 substituents (depending on the number of available substitution positions ) each independently selected from halo, cyano, C1-C4 alkyl (optionally substituted with 1, 2 or 3 F atoms), -O- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 F atoms) and -S- (C1-C4 alkyl) (optionally substituted with 1, 2 or 3 F atoms) with the proviso that only C1-C4 alkyl can be a substituent for the H of any moiety -NH- present in a group bicyclic heteroaromatic of 8, 9 or 10 members; or a pharmaceutically acceptable salt thereof; with the proviso that: (a) the cyclic part of the group of formula (i) must contain at least three carbon atoms and no more than seven atoms in the ring; (b) when -X- is -CH = CH-, then the cyclic part of the group of formula (i) must contain at least five carbon atoms; (c) when -Z is -OH or -O- (C1-C3 alkyl), then -X- is -CH2-; (d) when -Y- is -O- then p cannot be 0; (e) the compound 3 - [(phenylmethyl) - (3S) -3-pyrrolidinylamino] -propanonitrile is excluded; and (f) the compound (See formula) is excluded. |
| priorityDate | 2003-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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