| abstract |
Procedure for obtaining peptidesnbicyclicn n n Procedure for obtaining the products ofnthe attached formula, in which AA1, AA2, AA3, AA4, AA1 ', AA2', AA3 ',n and AA4 'are independently alpha-amino acids ofnL or D configuration, if applicable, proteinogenic or notnproteinogenic, and where at least two are cisterns ornN-alkyl tanks, which comprises the formation ofnsolid phase disulfide bridge intermolecular dimer fromnof linear precursors, where the disulfide bridge is cleaved from thensolid support and biciclado in solution. The products obtainednthey have biological activity and usefulness in therapy, eg asnanti-tumor |