| abstract |
Compound of formula (I): (See formula) where: - R3 represents a hydrogen atom, and R1 and R2 form, together with the carbon atoms that carry them, a benzene, naphthalene or quinolein cycle, each of these being cycles possibly substituted with one or several substituents, identical or different, selected from hydrogen, halogen and linear or branched (C1-C6) alkyl optionally substituted with one or more halogen atoms, or R1 represents a hydrogen atom and R2 and R3 together with the carbon atoms that carry them, a benzene, naphthalene or quinolein cycle, each of these cycles being eventually substituted with one or several substituents, identical or different, selected from hydrogen, halogen and (C1-) alkyl C6) linear or branched optionally substituted with one or more halogen atoms, - n represents 1 or 2, - -X- represents a group selected from - (CH2) mO-Ak-, - (CH2) m-NR4-Ak- , - (CO) -NR4-Ak- and - (CH2) m-NR4- (CO) -, m represents an integer between 1 and 6 inclusive, Ak represents a linear or branched (C1-C6) alkylene chain optionally substituted with a hydroxyl group and R4 represents a hydrogen atom or a linear or branched (C1-C6) alkyl group, - Ar represents an aryl or heteroaryl group, its optical isomers, as well as its addition salts of a pharmaceutically acceptable acid, it being understood that: optical isomers are understood as the enantiomers and diastereoisomers, by aryl group means phenyl, biphenyl or naphthyl, each of these groups being optionally substituted with one or more groups, identical or different, selected from halogen, linear or branched (C1-C6) alkyl, linear (C1-C6) alkoxy or branched, hydroxyl, cyano and trihaloalkyl (C1-C6) linear or branched, and by heteroaryl group is meant a mono- or bicyclic aromatic group of 5 to 12 links containing one, two or three selectable heteroatoms cited from oxygen, nitrogen or sulfur, it being understood that the heteroaryl may be optionally substituted with one or more groups, identical or different, selected from halogen, linear or branched (C1-C6) alkyl, linear or C1-C6 alkoxy branched, hydroxyl and trihaloalkyl (C1-C6) linear or branched. |