| abstract |
A hydroxy-tetrahydro-naphthalenylurea derivative of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: in which n represents an integer from 1 to 6; R1 represents hydrogen or C1-6 alkyl; R2, R3 and R4 independently represent hydrogen, halogen, hydroxy, C1-6 alkylamino, di (C1-6 alkyl) amino, C3-8 cycloalkyl amino, C1-6 alkoxycarbonyl, phenyl, benzyl, heterocycle, sulfonamide, C1- alkanoyl 6, C 1-6 alkanoyl amino, carbamoyl, C 1-6 alkyl carbamoyl, cyano, C 1-6 alkyl optionally substituted by cyano, C 1-6 alkoxy carbonyl or mono-, di-, or tri-halogen, optionally substituted C 1-6 alkoxy by mono-, di-, or tri-halogen, phenoxy optionally substituted by halogen or C1-6 alkyl, or C1-6 alkylthio optionally substituted by mono-, di-, or tri-halogen; X represents O, S or N-R5; and R5 represents hydrogen, benzyl or C1-6 alkyl. |