abstract |
A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein: Z is - (CH2) n-; ;, where R10 is absent; or, where R3 is absent; the single dotted line represents an optional double bond; the double dotted line represents an optional single link; n is 0-2; R1 and R2 are independently selected from the group consisting of H, C1-C6 alkyl, fluoro-C1-C6 alkyl, difluoro-C1-C6 alkyl, trifluoro-C1-C6 alkyl, C3-C7 cycloalkyl, C2-C6 alkenyl, aryl (C1-C6) alkyl, aryl-C2-C6 alkenyl, heteroaryl (C1-C6) alkyl, heteroaryl (C2-C6) alkynyl, hydroxy (C1-C6) alkyl, (C1-C6) alkoxy-(C1-C6) alkyl, amino (C1-C6) alkyl, aryl and thio-C1-C6 alkyl; or R1 and R2 together form a group = O; R3 is H, hydroxy, C1-C6 alkoxy, -NR18R19, -SOR16, -SO2R17, -C (O) OR17, -C (O) NR18R19, C1-C6 alkyl, halogen, fluoro-C1-C6 alkyl, difluoro-C1-C6 alkyl, trifluoro-C1-C6 alkyl, C3-C7 cycloalkyl, C2-C6 alkenyl, aryl (C1-C6) alkyl, aryl-C2-C6 alkenyl, heteroaryl-alkyl ( C1-C6), heteroaryl (C2-C6) alkenyl, hydroxy (C1-C6) alkyl, amino (C1-C6) alkyl, aryl, thio-C1-C6 alkyl, (C1-C6) alkoxy - (C1-C6) alkyl or (C1-C6) alkyl-amino-C1-C6 alkyl. |