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filingDate 2006-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ea0d1c29afe2dfb501c00f48df7515f
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publicationDate 2008-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2291120-A1
titleOfInvention SYNTHESIS AND USE OF THE CU-FENANTROLINA-IODOHIPURIC ACID COMPLEX AND RELATED COMPOUNDS AS ANTITUMORAL PHARMACOS.
abstract Synthesis and use of the Cu-fenantroli- ternary complex iodohipuric acid na-and related compounds as antitumor drugs.n n n The present invention relates to complexesnternaries formed by Cu (II),n1,10-phenanthroline or 2,2-bipyridylnand different hippuric acids of general formula (I):n n \ vskip1.000000 \ baselineskipn n n \hskip2cm [Cu\nA\ B_{2}]^{+}C\cdot nH_{2}O \hskip2cm n(I) \ hskip2cm [Cu \ A \ B_ {2}] + C \ cdot nH_ {O} \ hskip2cm (I)n n \ vskip1.000000 \ baselineskipn n n where A is selected from:nI-hip, Hip, BGG and BI GG; B is selected fromnBetween: phen and bpy; C is selected fromnI-hip <->, Hip <->, B <1> GG <->, BGG <-> andnI <->; and n, if it exists, are the crystallization waters that cannvary between 1 and 7. These compounds in solution have anhigh stability in the form of Cu (I) complexes, which actnat the DNA level and, therefore, are useful as antitumor agents,nparticularly in human cancer and especially cancer ofnlung.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2407164-A1
priorityDate 2006-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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