http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2289945-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa5b188f2c01cc60c10fa482edd2f4ec |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-813 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-813 |
| filingDate | 2006-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2008-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcf777f08d1f73a604bea2e1d88cb738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed089bc823eef0a8e41b2361cce55570 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bbe76badfa6d6182ae7fe9bb30932d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2098d18eb0c8d81a1c42aaf4829da87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b32e08daa868d5333d22dd8a65cc1704 |
| publicationDate | 2008-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2289945-B1 |
| titleOfInvention | PROCEDURE FOR OBTAINING TWO ADVANCED INTERMEDIATES AND ITS USE FOR OBTAINING ATORVASTATIN CALCICA AMORFA. |
| abstract | Procedure for obtaining twonAdvanced intermediates and their use for obtaining atorvastatinnCalcium amorphous.n n n The present invention provides a process for obtaining 2- {6- (4R, 6R) - {2- [3-phenyl-4-phenylcarbamoyl-2- (4-fluorophenyl) -5-isopropylpyrrol-1-yl] ethyl } -2,2-dimethyl-1,3- dioxan-4-yl} tert-butyl acetate and 6- (4R, 6R) - {2- [3-phenyl-4-phenylcarbamoyl-2- (4-fluorophenyl) -5-isopropylpyrrol-1-yl] ethyl} tetrahydro-4-hydroxypyran-2-one, key intermediates in the preparation of calcium atorvastatin. The procedure consists in reacting 2-phenyl-1- (4-fluorophenyl) ethanone with 1-bromo-3-methyl-2-butanone under atmosphere inert and in the presence of a strong base, then react the resulting compound (±) -2-phenyl-1- (4-fluorophenyl) -5-methylhexan-1,4-dione with 2 - [(4R, 6R) -6- (2-aminoethyl) -2,2-dimethyl-1,3-dioxan-4-yl] tert-acetate butyl at reflux of toluene and heptane in the presence of an acid catalyst to obtain {6- (4R, 6R) - {2- [3-phenyl-2- (4-fluorophenyl) -5-isopropylpyrrol-1-yl] ethyl} -2,2-dimethyl-1,3-dio- xan-4-yl} tert-butyl acetate, a new intermediate from which, after various stages of synthesis that include halogenation with a halosuccinimide and carbonylation with carbon monoxide in the presence of aniline, said advanced intermediates are obtained for obtaining atorvastatin calcium. The use of these intermediates to obtain calcium atorvastatin is also provided. amorphous after a series of stages of hydrolysis, sodium salt formation and isolation of amorphous raw calcium atorvastatin, which is purified to obtain a high quality product. |
| priorityDate | 2006-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.