| abstract |
A compound of structure, in which ** formula ** is a saturated ring of four, five or six members and X is C, O or S; with the proviso that the ring is a fully saturated carbon ring in which X in the ring can be a unique substitution of any C, O or S, except that X cannot be O when it is adjacent to the carbon of the pyrazolo ring and R1 is pyridine and R2 is a sulfonyl phenyl or thienyl; R1 is substituted or unsubstituted phenyl; substituted or unsubstituted pyridine; Substituted or unsubstituted pyridine N-oxide; substituted or unsubstituted quinoline; Substituted or unsubstituted quinoline N-oxide; substituted or unsubstituted naphthyridine; substituted or unsubstituted pyrazine; furilo substituted or unsubstituted thiazolyl; substituted or unsubstituted imidazolyl; substituted or unsubstituted pyrazolyl; or substituted or unsubstituted thiophenyl; wherein the substitution may be one or more of the following: (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) alkoxy, (C2-C6) alkenyloxy, alkynyloxy (C2-C6), alkylthio (C1-C6), alkyl (C1-C6) sulfinyl, alkyl (C1-C6) sulfonyl, alkyl (C1-C6) amino, di- [alkyl (C1-C6)] amino, alkoxy (C1-C6) carbonyl, N-alkyl (C1-C6) -carbamoyl, N, N-di- [alkyl (C1-C6)] carbamoyl, alkanoyl (C2-C6), alkanoyloxy (C2-C6), alkanoyl ( C2-C6) amino, N-(C1-C6) -alkanoyl (C2-C6) amino, alkenoyl (C3-C6) amino, N-alkyl (C1-C6) -alkenoyl (C3-C6) amino, alkynyl ( C3-C6) amino, N-(C1-C6) alkyl-(C3-C6) alkyl, amino, N-(C1-C6) sulfamoyl, N, N-di- [(C1-C6) alkyl] sulfamoyl, alkane (C1-C6) sulfonylamino, N-(C1-C6) alkyl-alkano (C1-C6) sulfonylamino, carboxamide, thiophenyl, aminophenyl, trifluoromethyl, halo, trifluoromethoxy, hydroxymethyl, N-pyrrolidino, N-morpholino, phenylthio, dialkyl ( C1-C4) aminomethyl, methoxyphenyl, amino, hydroxy, carboxyl, phenyl, arylalkyl. |