| abstract |
A compound of ** formula ** an N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or an isomeric stereochemical form thereof, where -a1 = a2-a3 = a4- represents a bivalent radical of formula -CH = CH-CH = CH- (a-1); -N = CH-CH = CH- (a-2) -N = CH-N = CH- (a-3) -N = CH-CH = N- (a-4) -N = N-CH = CH - (a-5) -b1-b2-b3- represents a bivalent radical of the formula -O-CH2-CH2- (b-1); -O-CH = CH- (b-2); -S-CH2-CH2- (b-3); -S-CH = CH- (b-4); -CH2-CH = CH- (b-5); n is 0, 1, 2, 3 or 4; and in the case that -a1 = a2-a3 = a4- is (a-1), then n can also be 5; m is 0, 1, 2 or 3; q is 0, 1 or 2; p is 1 or 2; R1 is hydrogen; aryl; formyl; C1-6 alkylcarbonyl; C1-6 alkyl; C1-6 alkyl oxycarbonyl; C1-6 alkyl substituted with formyl, C1-6 alkylcarbonyl, C1-6 alkyl oxycarbonyl, C1-6 alkylcarbonyloxy; C 1-6 alkyl-C 1-6 alkylcarbonyl substituted with C 1-6 alkyl-oxycarbonyl; each R2 is independently hydroxy, halo, C1-6 alkyl optionally substituted with cyano or with -C (= O) R6, C3-7 cycloalkyl, C2-6 alkenyl optionally substituted with one or more halogen or cyano atoms, C2 alkynyl 6 optionally substituted with one or more halogen or cyano atoms, C1-6-oxycarbonyl alkyl, carboxyl, cyano, nitro, NR13R14, polyhalomethyl, polyhalomethylthio, -S (= O) pR6, -NH-S (= O) pR6, -C (= O) R6, -NHC (= O) H, -C (= O) NHNH2, -NHC (= O) R6, -C (= NH) R6 |