| abstract |
A compound of formula 1 Q1 and Q2 are independently selected from hydrogen and substituted and unsubstituted alkyl and aryl, and Q1 and Q2 can form a ring with G; Q3 is selected from mercapto and alkoxy, aryloxy, thioether, amino, alkyl, cycloalkyl, saturated and partially saturated heterocycle, and substituted and unsubstituted aryl; Q4-Q8 are independently selected from hydrogen, OPO (OH) 2, hydroxyl, alkyl, amino and nitro. Y and G are each oxygen or -N-H; D is nitrogen; E is carbon or nitrogen; Q9 is hydrogen; A is a carbocycle or heterocycle, which is optionally further substituted; and B is decahydroisoquinoline; or a pharmaceutically acceptable salt thereof, where alkyl refers to linear or branched groups having 1 to 8 carbon atoms; cycloalkyl represents a saturated or partially unsaturated mono- or polycarbocyclic ring having 5 to 14 carbon atoms; alkoxy represents -O-alkyl; aryl refers to a 5- to 14-membered aromatic carbocyclic or heterocyclic monocyclic or polycyclic ring; aryloxy represents -O-aryl; carbocycle represents an aromatic or saturated or partially unsaturated monocyclic or polycyclic ring of 5 to 14 members; heterocycle represents an aromatic or saturated or partially saturated monocyclic or polycyclic ring of 5 to 14 members having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur; thioether represents -S-aryl, -S-heterocycle, -S-C5-C7 cycloalkyl and -S-alkyl; amino represents -NL1L2 where L1 and L2 are independently selected from oxygen, carbocycle, heterocycle, alkyl, sulfonyl, and hydrogen, or NC (O) L3 where L3 is alkyl, alkoxy, hydrogen; or -NL1L2; sulfonyl represents -SO2L5 where L5 is alkyl, aryl, cycloalkyl, heterocycle or amino; where the substituents for alkyl and aryl are selected from mercapto, thioether, nitro, amino, aryloxy, halogen, hydroxyl, acyl, aryl, cycloalkyl, and saturated and partially unsaturated heterocycle; and where the substituents for heterocycle and cycloalkyl are selected from those mentioned above for alkyl and aryl plus aryl and alkyl. |