http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2286951-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8c689ab1a74e2bc8953337169eb69a1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2006-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_010902d679729db79ff8bd272d873837 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd659c5380daab9730a6569538f8e992 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec82f78d162b144b29130e238918cad3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68c705c23f6dcc79096a29e984094ab4 |
| publicationDate | 2007-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2286951-A1 |
| titleOfInvention | BIOADHESIVE NANOPARTICLES FOR THE ADMINISTRATION OF BIOLOGICALLY ACTIVE MOLECULES. |
| abstract | Bioadhesive nanoparticles fornadministration of biologically active molecules.n n n The invention relates to nanoparticles for the administration of biologically active molecules, which they comprise a biodegradable polymer, preferably the copolymer of methyl vinyl ether and maleic anhydride (PVM / MA), and thiamine. These nanoparticles are easy to produce, and give excellent characteristics of bioadhesion, size and zeta potential that makes them suitable for the administration of active molecules. The procedure for obtaining the nanoparticles is performed by simple incubation for a short period of time with the preformed nanoparticles in an aqueous medium. The biologically active molecule can be incorporated during the nanoparticle formation process by desolvation or after thiamine modification. Orally, these nanoparticles develop bioadhesive interactions with the gastrointestinal mucosa, including lymphoid tissue associated with mucous membranes (Peyer's plaques), which is useful for increasing the oral bioavailability of various drugs or for inducing immune responses at the mucosal level. Thus, when the nanoparticles contain an antigen, inside the matrix of the nanoparticles, the resulting mixture is capable of inducing strong immune responses against the encapsulated antigen. This stimulating effect of the immune response is useful for vaccination and immunotherapy. |
| priorityDate | 2006-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.