abstract |
A compound selected from the ** Formula ** (I) or ** Formula ** (II), where A is selected from the group consisting of: aryl (optionally substituted with 1 to 4 substituents independently selected from the group consisting of halogen, C1-8 alkyl, C1-8 alkoxy, hydroxy, C1-8 hydroxyalkyl, C1-8 hydroxyalkoxy, (halo) 1-3 (C1-8) alkyl and (halo) 1-3alko-xi (C1-8)) and heteroaryl selected from furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, quinolinyl and isoquinolinyl (said heteroaryl being optionally substituted on 1 to 4 ring members carbon available with a substituent selected from the group consisting of halogen, C1-8 alkyl, C1-8 alkoxy, hydroxy, C1-8 hydroxyalkyl, C1-8 hydroxyalkoxy, (halo) 1-3 (C1-8) alkyl and (halo ) 1-3-C1-8 alkoxy; and eventually substituted on the ring members of át nitrogen atoms available with a substituent selected from the group consisting of C1-8 alkyl, C1-8 hydroxyalkyl and (halo) 1-3 (C1-8) alkyl); B is heteroaryl selected from furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, quinolinyl, isoquinolinyl and quinoxalinyl (said heteroaryl being optionally substituted on the heteroaryl to 4 on the heteroaryl 4 ring of carbon atoms available with a substituent selected from the group consisting of halogen, C1-8 alkyl, C1-8 alkoxy, hydroxy, C1-8 hydroxyalkyl, C1-8 hydroxyalkoxy, (halo) 1-3 (C1-8) alkyl and (halo) 1-3 (C1-8) alkoxy; and optionally substituted on the ring members of available nitrogen atoms with a substituent selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C1-8 hydroxyalkyl, (halo) 1-3 (C1-8) alkyl and oxide); and its acid addition salts, quaternary ammonium salts and pharmaceutically acceptable N-oxides. |