| abstract |
THIS INVENTION IS RELATED TO SOME COMPOUNDS WITH FORMULA (I) AND ITS PHARMACEUTICALLY ACCEPTABLE DERIVATIVE SALTS, WHOSE SUBSTITUTES CORRESPOND TO THE DEFINED IN THE SPECIFICATION, WHICH ARE STIMULATORS OF THE HORMONE SECRETION OF GROWTH AND INCREASING INCREASE . THE COMPOUNDS OF THIS INVENTION ARE USEFUL IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS, CONGESTIVE CARDIAC INSUFFICIENCY, AGRICULTURAL ASSOCIATED FRAGILITY, OBESITY; ACCELERATION OF THE RECONSTITUTION OF OSEAS FRACTURES, ATTENTION OF THE PROTEIN CATABOLIC RESPONSE AFTER AN IMPORTANT OPERATION, REDUCTION OF THE CAQUEXY AND LOSS OF PROTEINS DUE TO CHRONIC DISEASES, ACCELERATION OF THE CURING OF PENTED OR RECENT PENALTIES, OR ACCESSORIES THAT HAVE SUFFERED AN IMPORTANT SURGICAL TREATMENT; IMPROVEMENT OF MUSCLE RESISTANCE, MOBILITY, MAINTENANCE OF SKIN THICKNESS, METABOLIC HOMEOSTASIS OR RENAL HOMEOSTASIS. THE COMPOUNDS OF THE PRESENT INVENTION ARE ALSO USEFUL IN THE TREATMENT OF OSTEOPOROSIS WHEN USED IN COMBINATION WITH: A BIFOSPHONATE COMPOUND LIKE THE ALENDRONATE; STROGENS, PREMARINE, AND, OPTIONALLY, PROGESTERONE; A ESTONIC AGONIST OR ANTAGONIST; OR CALCITONINE, AND USEFUL DERIVED PHARMACEUTICAL COMPOSITIONS. IN ADDITION, THE PRESENT INVENTION IS RELATED TO USEFUL PHARMACEUTICAL COMPOSITIONS TO INCREASE ENDOGENOUS PRODUCTION OR HORMONE RELEASE OF HUMAN OR ANIMAL GROWTH, WHICH ARE COMPOSED OF AN EFFECTIVE AMOUNT OF A COMPOSITE OF THE PRESENT INVENTION AND GROWTH HORMONE, SELECTED BETWEEN GHRP 6, HEXARELINE, GHRP 1, GROWTH HORMONE RELEASE FACTOR (GRF), IGF 1, IGF 2 OB HT920. THE INVENTION IS ALSO RELATED TO USEFUL INTERMEDIATE PRODUCTS TO PREPARE COMPOUNDS WITH FORMULA (I). |