abstract |
Compounds of formula (See formula) in which R 1 represents 1-aza-bicyclo [2.2.2] oct-3-yl, R 2 represents hydrogen or C1-C6 alkyl, R 3 represents hydrogen, halogen or C1-C6 alkyl , A represents oxygen or sulfur, and ring B represents benzo, pyrimido, pyridazole or pyridazine, which if necessary are substituted with moieties selected from the hydrogen group, halogen, C1-C6 alkanoyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6 acylamino, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylamino, heteroarylcarbonylamino, arylcarbonylamino, C1-C4 alkylsulfonylamino, di- (alkylsulfonyl (C1-C4)) amino, arylsulfonylamino, di- (arylsulfonyl) amino, cycloalkyl (C3-C6) carbonylmethyl, 1,3-dioxa-propane-1,3-diyl, amino- (hydroxyimino) methyl and benzo, and salts, solvates and solvates thereof. |