| abstract |
Stable colloidal suspension of submicron structured particles that can be used, especially for the vectorization of active PA principle (s), these particles being individualized (discrete) supramolecular arrangements: * based on amphiphilic, linear polyamino acids (PAA), with chains peptides and comprising at least two different types of recurring amino acids hydrophilic AAI and hydrophobic AAO, the amino acids of each type being identical or different from each other; * capable of associating in colloidal suspension in the undissolved state, at least one AP and releasing it, especially in vivo, in a prolonged and / or delayed manner; * and stable in aqueous phase at pH between 4 and 13 in the absence of surfactant (s); characterized: - because AAI hydrophilic recurring amino acids are AANI hydrophilic neutral amino acids with the exception of asparagine; - because AAO hydrophobic recurring amino acids are AANO hydrophobic neutral amino acids; - and because the recurrent amino acids of each type AANI and AANO are identical or different from each other. |