http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2278017-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcb2ba7c6861e5a119827dad565269e5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 2002-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1f153a3f30d6c3655cb4f3e17c144e2 |
| publicationDate | 2007-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2278017-T3 |
| titleOfInvention | METHOD FOR THE PREPARATION OF (S) - (+) - Y (R) - (-) - 10,11-DIHIDRO-10-HIDROXI-5H-DIBENZ / B, F / AZEPINA-5-CARBOXAMIDA. |
| abstract | A method for the preparation of (S) - (+) - 10, 11-dihydro-10-hydroxy-5H-dibenz / b, f / azepine-5-carboxamide, comprising the steps of: (1) reacting ( ñ) -10, 11-dihydro-10-hydroxy-5H-dibenz / b, f / racemic azepine-5-carboxamide with tartaric acid anhydride (2R, 3R) -di-O, O '' - substituted to give a Separable mixture (1: 1) of 10-O-di-O, O '' tartrate diastereoisomeric hemiesters - substituted by (ñ) -10, 11-dihydro-10-hydroxy-5H-dibenz / b, f / azepine- 5-carboxamide; (2) precipitation of the less soluble soluble 10-O-di-O, O '' - substituted tartrate hemiester formed in step (1) by adding water and separating it by filtration; and (3) catalyzed hydrolysis based on the less soluble 10-O-di-O, O '' - substituted tartrate hemiester hemiester obtained in step (2) to give the (S) - (+) - 10, 11- dihydro-10-hydroxy-5H-dibenz / b, f / optically pure azepine-5-carboxamide, in which the substituted tartaric acid anhydride (2R, 3R) -di-O, O '' - has the formula: where each R is the same and is C1 to C6 alkyl, or each R is phenyl. |
| priorityDate | 2001-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.