| abstract |
A compound of formula (I), (See formula) or a pharmaceutically acceptable derivative thereof, in which V represents - (CH2) d (O) e-, -CO- or -CH (C1-6 alkyl) -; W is -O-, -S (O) a- or -N (R 1) -R 1 represents H, C1-6 alkyl, (CH2) bCOR 2, CO (CH2) bNR 2 R 3, SO2R 2, ( CH2) cOR 2, (CH2) cNR 2 R 3 or (CH2) bhet 1; het 1 represents a saturated or unsaturated heterocycle of 3 to 8 atoms containing one or more heteroatoms selected from O, N or S, optionally substituted with C1-6 alkyl; X and Y independently represent H, C1-6 alkyl, halogen, OH, CF3, OCF3, OR 4; Z represents - (CH2) f (O) g-, -CO- or -CH (C1-6 alkyl) -; Ring A represents a saturated heterocycle containing 4-7 membered N, optionally substituted with OH and wherein optionally at least one ring N is substituted with O; Ring B represents phenyl or an unsaturated heterocycle containing 4-7 membered N, optionally substituted with OH, halogen, CN, CONH2, CF3, OCF3 and in which optionally at least one ring N is substituted with O; R 2 and R 3 independently represent H, C1-6 alkyl [optionally substituted with OH, halogen, N (C1-6 alkyl) 2 or C1-6 alkyloxy], C1-6 alkyloxy, N (C1-6 alkyl) 2 or [C3-8 cycloalkyl]; or R 2 and R 3, together with the nitrogen atom to which they are attached, independently represent a heterocycle of 3 to 8 atoms, optionally substituted with C 1-6 alkyl; R 4 represents linear or branched C1-6 alkyl, a and c independently represent 0, 1 or 2; b, e and g independently represent 0 or 1; and d and f independently represent 1 or 2. |