abstract |
A compound, including all enantiomeric and diastereoisomeric forms and pharmaceutically acceptable salts thereof, said compound having the formula: wherein R is: a) Or [CH2] kR3 or b) NR4aR4b; R3 is substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted hydrocarbyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl or alkylenearyl, substituted or unsubstituted heteroaryl or alkyleneheteroaryl; the index k is from 0 to 5; R4a and R4b are each, independently of each other: a) hydrogen; or b) [C (R5aR5b)] mR6; each unit R5a and R5b are, independently of each other, hydrogen, linear, branched or cyclic C1-C4 alkyl and mixtures thereof; R6 is ¿OR7, ¿N (R7) 2, ¿CO2R7, ¿WITH (R7) 2; C1-C4 substituted or unsubstituted alkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R7 is hydrogen, a water-soluble cation or C1-C4 alkyl; the index m is from 0 to 5; R1 is: a) substituted or unsubstituted aryl; or b) substituted or unsubstituted heteroaryl; two R2 units of the same carbon atom join to form a spirocyclic ring having 4 to 7 atoms, the rest of the R2 units are independently selected from the group consisting of: a) hydrogen; b) Or (CH2) jR8; c) ¿(CH2) jNR9aR9b; d) (CH2) jCO2R10; e) ¿(CH2) jOCO2R10 f) ¿(CH2) jCON (R10) 2; and g) two R2 units can be joined to form a carbonyl unit; R8, R9a, R9b and R10 are each, independently of each other, hydrogen, C1-C4 alkyl and mixtures thereof; R9a and R9b can be joined to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; two R10 units can be joined to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; j is an index from 0 to 5 and the index n is from 3 to 5. |