http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2266266-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C259-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 |
| filingDate | 2001-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fb4585f064dbe77daaa62e496c75159 |
| publicationDate | 2007-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2266266-T3 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF DISCODERMOLIDE AND ITS ANALOGS. |
| abstract | A process for preparing a compound of formula V which comprises, in a first step, the coupling of a ketone compound of formula I With an aldehyde compound of formula II in the presence of a dialkyl boron hydride or triftalate, an amine base, and a polar organic solvent to obtain a -hydroxyketone of formula III In a second step, reducing the ketone compound obtained in the first step by treating with the borohydride reagent in a polar organic solvent and a protonic solvent to obtain a 1,3-diol of formula IV And, in a third step, the lactonization and deprotection of the acid labile hydroxyl protecting groups of the 1,3 diol obtained in the second step by treatment with hydrogen halide dissolved in a polar solvent or solvent mixture to obtain the desired compound of formula V, wherein R 1 is (C 1-6) alkyl, benzyl or an acid labile hydroxyl protecting group; R2 is (C1-6) alkyl or benzyl; R3 is hydrogen, (C1-6) alkyl, benzyl, C (O) (C1-12) alkyl, C (O) Ph, C (O) O (C1-12) alkyl, C (O) OPh, C ( O) NH (C1-12) alkyl, C (O) NHPh or an acid labile hydroxyl protecting group; R3 "is an acid-labile hydroxyl protecting group; R4 is hydrogen or methyl; and X is O, NH, NCH3, S or CH2, with the proviso that X is O and R3 is an acid-labile hydroxyl protecting group In the compound of formula I, the intermediate "-X-R3" in the compound of formula V is OH. |
| priorityDate | 2000-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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