abstract |
A compound of ** formula ** or a pharmaceutically acceptable salt thereof, wherein: Rx are independently selected from T-R3, or L-Z-R3; Ry are independently selected from T-R8 or LZ-R3, wherein R8 is chosen from an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms or a heterocyclyl ring having 5-10 atoms in the ring, -halo, -OR, -C (= O) R, -CO2R, -COCOR, -COCH2COR, -NO2, -CN, -S (O) R, -S (O) 2R, -SR, -N (R4) 2, -CON (R7) 2, -SO2N (R7) 2, -OC (= O) R, - N (R7) COR, -N (R7) CO2 (C1-6 aliphatic), -N (R4) N (R4) 2, - C = NN (R4) 2, -C = N-OR, -N (R7) CON (R7) 2, -N (R7) SO2N (R7) 2, -N (R4) SO2R, or -OC (= O) N (R7) 2; R1 is T- (Ring D); Ring D is a 5-7 membered monocyclic ring or an 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl, said heteroaryl or heterocyclyl ring having 1-4 heteroatoms in the ring selected from nitrogen, oxygen or sulfur, where each substitutable carbon of the Ring D ring is independently replaced by oxo, T-R5, or VZ-R5, and each substitutable nitrogen of the Ring D ring is independently replaced by -R4; T is a valence bond or a C1-4 alkylidene chain; Z is a C1-4 alkylidene chain. |