| abstract |
A topically or locally administrable pharmaceutical composition for treating allergic diseases of the eyes, nose, skin, ear or lung comprising a tonicity adjusting agent in an amount sufficient to cause the composition to have an osmolality of 150-450 mOsm, a pharmaceutically acceptable preservative and a disulfide derivative of the formula wherein X = -NHC (= O) NH-R; R = H; phenyl (not) substituted; benzyl (not) substituted; or C1-C8 alkyl or alkenyl, optionally substituted with or terminated in OH, OR2, NR3R4; C4-C7 cycloalkyl, substituted (non) aryl, or 5-7 membered (non) substituted heterocycle ring; wherein the optional substituents are selected from the group consisting of C1-C6 alkyl or C1-C6 alkoxy; halogen; OH; CN; CF3; NO2; and CO2R2; R2 = C1-C3 alkyl; and R3 and R4 are independently H; benzyl; C1-C8 alkyl or C1-C8 alkenyl; C4-C7 cycloalkyl; aryl (not) substituted; or 5-7 membered heterocyclic ring (not) substituted; wherein the optional substituents are selected from the group consisting of C1- alkyl or alkoxy |