| abstract |
New derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts are described, which have vasodilator activity with a diminished tolerance effect, of general formula (I) in which A and B indistinctly represent any of the groups -ONO2 and -Z-CO -R, where Z is an oxygen or sulfur atom, and R is a C1-C4 alkyl, aryl or aralkyl group, optionally substituted, or the group (a), in which R1 à is hydrogen or a C1-C4 alkyl group , aryl or aralkyl, optionally substituted, so that always one of A or B is -ONO2, but never both at the same time, when Z is a sulfur atom R is a C1-C4 alkyl group, aryl or aralkyl, if any substituted, and when Z is an oxygen atom R is the group (a). |