| abstract |
A compound of the formula (See formula) in which Y is C1-C6 alkylene; R1 is phenyl which is substituted with 1 or 2 identical or different substituents selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkoxy, mono (or di or tri) halo (C1-C6 alkyl), nitro, amino, (C1-C6 alkyl) amino, di (C1-C6 alkyl) amino, (C1-C6 alkyl) thio, (C1-C6 alkyl) sulfonyl, cyclo (C3-C6 alkyl) sulfonyl , aminosulfonyl, (C1-C6 alkyl) aminosulfonyl, di (C1-C6 alkyl) aminosulfonyl, pyrrolidinylsulfonyl, morpholinyl sulfonyl, pyrrolylsulfonyl, pyridylsulfonyl, pyrrolyl and pyridyl; R2 is phenyl which is substituted with 1 or 2 identical or different substituents selected from the group consisting of C1-C6 alkyl, mono (or di or tri) halo (C1-C6 alkyl), mono (or di or tri) halo (C1-C6 alkyl) sulfonyloxy, halogen, (C1-C6 alkylene) dioxy, C1-C6 alkoxy, (C1-C6 alkoxy) carbonyl, (C1-C6 alkoxy) (C1-C6 alkoxy) ( C1-C6 alkoxy), hydroxy, diphenyl (C1-C6 alkyl) silyloxy, tri (C1-C6 alkyl) silyloxy, hydroxy (C1-C6 alkyl), cyano, amino, [mono (or di or tri) halo (C1-C6 alkyl) carbonyl] amino, (C1-C6 alkyl) amino, N- (C1-C6 alkyl) - [mono (or di or tri) halo (C1-C6 alkyl) carbonyl] amino, pyrrolidinyl and morpholinyl which may be substituted with (C1-C6 alkoxy) C1-C6 alkyl or C1-C6 alkyl; R3 is hydrogen; and R4 is (2,6-dimethylmorpholino) (C1-C6 alkyl); (3, 3-dimethylmorpholino) (C1-C6 alkyl); (cis-3, 5-dimethylmorpholino) (C1-C6 alkyl); ((3S, 5S) -3,5-dimethylmorpholino) (C1-C6 alkyl); ((3S, 5R) -3,5-dimethylmorpholino) (C1-C6 alkyl); (2-methoxymethylmorpholino) (C1-C6 alkyl); (3-methoxymethylmorpholino) (C1-C6 alkyl); (2-methoxymethyl-5-methylmorpholino) (C1-C6 alkyl); (2-methoxymethyl-5,5-dimethylmorpholino) (C1-C6 alkyl); (3, 5-dimethoxymethylmorpholino) (C1-C6 alkyl); or (2,3-dimethoxymethylmorpholino) (C1-C6 alkyl), and one of its salts. |