| abstract |
A compound of formula II wherein R4 is phenyl or C3-C7 cycloalkyl each of which is optionally mono-substituted by halogen, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, trihalomethyl or optionally mono- or di- amino (C1-C4) -substituted alkyl, or by N heterocyclyl containing from 5 to 7 ring atoms and optionally containing another heteroatom selected from O, S or N; R10 is halogen; R3 is H, C1-C4 alkyl, phenyl, pyridyl, morpholinyl, piperidyl, piperazyl or optionally mono- or ddi (C1, 4) -substituted alkyl, each of which is optionally substituted, for example by up to two substituents , selected separately from C1-C4 alkyl, halogen, hydroxy, C1-C4 alkoxy or optionally mono- or ddi (C1-C4) -substituted alkyl; Z is N or CH and X ¿is -NH-Y¿-, Oo S-where Y¿ is -CH2-, -CH2-CH2-, -CH (CH3) - or a direct bond, and derivative prodrug esters of same that they can be converted by solvolysis or dissociation under physiological conditions to the compound of formula II, which comprises the free hydroxyl group; and acid addition salts thereof. |