| abstract |
A compound of the formula I in which A1 is phenylene which may not be substituted or substituted with one or more identical or different substituents of the halogen series, (C1-C4) alkyl, CF3, -O-(C1-) alkyl C4) and -CN; ring A2, which comprises the two carbon atoms bearing the groups R2-SO2-NH and C (= X) -NH-, is a benzene ring, a pyridine ring, a thiophene ring or a pyrazole ring; R1 is (C1-C7) alkyl; or is phenyl, which may not be substituted or substituted with one or more identical or different substituents of the halogen series, (C1-C4) alkyl, phenyl, CF3, NO2, -O-(C1-C4) alkyl, alkylenedioxy (C1-C2), NH2, -NH-CO-(C1-C4) alkyl, -CN, -CO-NH2, -CO-OH and -CO-O-(C1-C4) alkyl; or, if the number n in the group R1-S (O) n- is 2, it is also NR5R6; R2 is aryl; R3 denotes one or more identical or different residues of the hydrogen, halogen, CF3, -O-(C1-C4) alkyl, -CN and (C1-C4) alkyl series; R5 and R6, independently of each other, are hydrogen or (C1-C9) alkyl, which may not be substituted or substituted with aryl or alkenyl (C2-C9) or cycloalkyl (C3-C9) or alkyl (C1-C4) -O-(C1-C3) alkyl; or R5 and R6, together with the nitrogen atom carrying R5 and R6, form a saturated or partially unsaturated heterocycle of 5 or 7 members which in addition to the nitrogen atom carrying groups R5 and R6 may contain another ring heteroatom of the series N, O and S, and may be substituted with one or more identical or different residues of the series of (C1-C3) alkyl, hydroxyalkyl (C1-C3), aryl, carbamoyl, hydroxy and oxo, and to which it may be condensed a benzene ring; aryl is phenyl or heteroaryl, which may all be substituted with one or more identical or different substituents of the halogen series, (C1-C4) alkyl, phenyl, CF3, NO2, -O-(C1-C4) alkyl, alkylenedioxy ( C1-C2), NH2, -NH-CO-(C1-C4) alkyl, -CN, -CO-NH2, -CO-OH and - CO-O-(C1-C4) alkyl; heteroaryl is a residue of a 5 or 6 membered monocyclic aromatic heterocycle containing one or two identical or different heteroatoms of the N, O and S series; n is 0 or 2; X is oxygen; in all its stereoisomeric forms and mixtures in all ratios, and their physiologically acceptable salts, in which only up to two nitro groups can be present in a compound of the formula I. |