| abstract |
THE PRESENT INVENTION REFERS TO THE FORMULA COMPOUNDS (I), THE NORMAL OR PHARMACEUTICALLY ACCEPTABLE FORMS AND THE STEREOCHEMICALLY ISOMERIC FORMS OF THE SAME, IN WHICH R SUP, 1} YR SUP, 2} EACH INDEPENDENTLY ; RENT C SUB, 1} C SUB, 3} EMBROS CONTAINING ONE OR TWO HETEROATOMOS SELECTED FROM OXYGEN, SULFUR OR NITROGEN; INDANIL; BIKE [2.2.1] USTITUDED; R SUP, 3} IS HYDROGEN, HALO OR ALQUILOXI C SUB, 1} C SUB, 6}; = C = X IS A BIVALENT RADICAL OF FORMULA = C = O; = C = CH ODIYL C SUB, 1} ORMULA: -CR SUP, 6} = CR SUP, 7} -; L IS HYDROGEN; RENT C SUB, 1} 1} OPTIONALLY REPLACED; OPTIONALLY REPLACED PIPERIDINYL; RENT SULFONYL OR ARILSULFONYL C SUB, 1} IT IS OPTIONALLY REPLACED PHENYL; HET SUP, 1} IS OPTIONALLY REPLACED MORPHOLINYL OR PYRIDINYL, OR, OR; AND HET SUB, 2} IS MORFOLINILO OR PIPERIDINILO OPTIONALLY REPLACED, THAT HAVE INHIBITING ACTIVITY OF PDE IV AND CYTOQUINE. THE INVENTION REFERS TO PROCESSES FOR THE PREPARATION OF FORMULA (I) COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS OF THEMSELVES. |