| abstract |
Procedure for the preparation of ziprasidone.nThe present invention relates to a process for the preparationnfromn5- (2- (4- (1,2-benzisothiazol-3-yl) -1-piperazinyl) ethyl) -6-chloro-1,3-dihydro-2H-indole-2-onenof formula I, or of a pharmaceutically acid addition saltnacceptable, solvate, hydrate or clathrate thereof, which comprisesnreacting a compound of formula II in which X is an atomnhalogen, with a compound of formula III, which may be saidncompound of formula III in the form of a free base or a salt ofnaddition with an organic or inorganic acid, characterized in thatnsaid compounds of formula II and III are reacted innpresence of a neutralizing agent, and of a solvent thatnunderstand acetonitrile. |