| abstract |
Compound selected from the group consisting of an olefinic amide of the formula: wherein R1 and R2 are independently hydrogen, halo, amino, nitro, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, perfluoro-alkyl lower sulfonyl, lower alkyl sulfonyl methyl or lower alkyl sulfinyl; R is - (CH2) m-R3 or alkyl containing from 2 to 4 carbon atoms; R3 is cycloalkyl having 3 to 8 carbon atoms; R4 is either an unsubstituted or mono-substituted five or six-link heteroaromatic ring connected through a carbon atom of the ring to the amino group shown, said five or six-link heteroaromatic ring containing 1 to 2 heteroatoms selected from the group formed. by sulfur or nitrogen, one of the heteroatoms being a nitrogen adjacent to the carbon atom of the connecting ring; said mono-substituted heteroaromatic ring being monosubstituted at a position of a carbon atom of the ring different from that adjacent to said connecting carbon atom, with a substituent selected from the group consisting of halo or m is 0 or 1; n is 0, 1, 2, 3 or 4; R7 is hydrogen or lower alkyl; and Ä designates a trans configuration with respect to the double bond; And "lower alkyl" indicates straight chain and branched chain alkyl groups having 1 to 7 carbon atoms; or a pharmaceutically acceptable salt thereof. |