| abstract |
A compound of ** formula ** for use in therapy, in which: R is selected from the group consisting of OH, SH, and NHSO2Rd; Rd is selected from the group consisting of NR6R7, alkyl, C 1-4 arylalkyl, C 2-4 arylalkyl, heteroaryl, C 1-4 heteroarylalkyl, C 2-4 heteroarylalkyl, heterocycle, and C 1-4 heterocycloalkyl; R6 and R7 are independently hydrogen, or a C1-4 alkyl group, or R6 and R7 together with the nitrogen to which they are attached form a 5- to 7-membered ring whose ring optionally contains an additional heteroatom that is selected from oxygen, nitrogen or sulfur; R1 is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, halosubstituted C1-10 alkyl, C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxy, halosubstituted C1-10 alkoxy, azide, (CR8R8) qS ( O) tR4, hydroxy, C1-4 hydroxyalkyl, aryl, C1-4 arylalkyl, aryloxy, C1-4 arylalkyl, heteroaryl, heteroarylalkyl, heterocycle, C1-4 heterocycloalkyl, C1-4 heteroarylalkyl, C2-10 heteroarylalkyl , C2-10 heterocycloalkenyl, (CR8R8) qNR4R5, C2-10-C alkenyl (O) NR4R5, (CR8R8) qC (O) NR4R5, (CR8R8) qC (O) NR4R10, S (O) 3H, S (O) 3R8, (CR8R8) qC (O) R11, C2-10-C alkenyl (O) R11, C2-10-C alkenyl (O) OR11 (CR8R8) qC (O) OR12, (CR8R8) qOC (O) R11, (CR8R8) qNR4C (O) R11, (CR8R8) qNHS (O) 2R17, (CR8R8) qS (O) 2NR4R5 or ¿heterocycloalkyl¿. |