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filingDate 2004-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09210d17e3591de3019e2e7af7052a14
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publicationDate 2006-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2245604-A1
titleOfInvention PROCEDURE FOR OBTAINING 2-AMINO-6-ALQUIL-AMINO-4,5,6,7-TETRAHYDROBENZOTIAZOLES.
abstract Procedure for obtainingn2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles.n n n The procedure for the preparation ofn2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzo-thiazolesn(I) where the asterisk (*) represents an asymmetric carbon and R1 isnC1-C6 alkyl; their enantiomers or mixtures ofnthemselves, their solvates, hydrates or acceptable saltsnPharmaceutically, it comprises: (a) reacting a compound (II)nwith a secondary amine, optionally in the presence of an acid andna solvent 1, to form an enamine; (b) optionally withdrawnsaid acid and said solvent 1, and then donreacting said enamine with sulfur in the presence of a solventn2; and (c) reacting the previously obtained compound withncyanamide to obtain the compound (I). Among the compounds (I)nis pramipexole, a compound with agonist activitynD-2 dopamine, useful for the treatment ofnParkinson's disease and schizophrenia.
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