| abstract |
NEW AMIDAS OF ISOQUINOLIN ACIDS - 3 - CARBOXILICS OF FORMULA I IN WHICH R 1 IS HYDROGEN OR CHLORINE, R 2 IS HYDROGEN, RENT, ALCOXI, CHLORINE, TRIFLUOROMETILO, HYDROXY OR BENCILOXE, OR CUALOXOU ROSE OR - [CH 2] XCFH (2F + 1-G) FG, BEING X = 0 Y 1, F = 1 - 5 YG = 1 UP TO (2F + 1), R 3 IS HYDROGEN, RENT, ALCOXI, FLUOR, CHLORINE, cyano, trifluoromethyl, hydroxy or benzyloxy, which may be optionally substituted, or fluoroalkoxy of the above formula, R SUP, 4 YR 5 are hydrogen, fluorine, chlorine, bromine, TR IFLUOROMETILO, cyano, or fluoroalkoxy of the above formula , INCLUDES PHYSIOLOGICALLY ACCEPTABLE SALTS; THEY ARE POWERFUL INHIBITORS OF PROLIL - 4 - HYDROXYLASE, WHICH DO NOT CAUSE ESTHEATOSIS. |