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filingDate 1993-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c66afe087559c6026510ba21f044e15d
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publicationDate 2005-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2245272-A6
titleOfInvention IMPROVEMENTS INTRODUCED IN THE OBJECT OF SPANISH PATENTS ES2059558 WHICH CONSISTS OF AN IMPROVED PROCESS FOR THE PRODUCTION OF A CYCLOSPORINE.
abstract Improvements introduced in the object of the patentnSpanish ES2059558 consisting of: "An improved process for then production of a cyclosporine. "n n n Improvements introduced in the object of the patentnSpanish ES2059558 consisting of these improvements in a process for thenproduction of a cyclosporine of formula II. The invention comprisesncultivate an organism to produce an intermediate cyclosporine ofnformula II where A is MeBmt, recover intermediate cyclosporinenand selectively oxidize it to produce a cyclosporine of formulanII where A is a residuen3'-deoxy-3'-oxo-MeBmt.nThe compounds thus obtained are useful in increasing thensensitivity to chemotherapeutic drug therapy orntime to increase the effectiveness of such therapy.n n n n one
priorityDate 1993-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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