| abstract |
A compound of the ** formula **, or a pharmaceutically acceptable salt, or an in vivo hydrolysable ester thereof, wherein in (I) C is a biaryl radical C¿C ", where C '' and C" they are independently aryl or heteroaryl rings such that the central fragment C is represented by any one of the following groups D to L, wherein groups D to L may be attached to rings A and B in any orientation; wherein, in groups D to L, R2a, R2b, R3a and R3b are: independently hydrogen or fluorine; where A and B are independently selected from Y where i) and / or ii) are linked as shown in (I) by position 3 to group C and substituted in position 5 as shown in (I) with ¿ CH2¿R1a and ¿CH2¿R1b; R1a and R1b are independently selected from hydroxy, ¿NHC (= W) R4, ¿OC (= O) R4, where W is O or S; R4 is hydrogen, amino, (1-4C) alkyl, NH (1-4C) alkyl, ¿N (di¿ (1-4C) alkyl), O (1-4C) alkyl or S (1-4C) ) alkyl, (2-4C) alkenyl, ¿(CH2) p (3-6C) ¿cycloalkyl ¿(CH2) p (3-6C) cycloalkenyl where p is 0, 1 or 2; wherein in a) HET1 is a 5-membered heteroaryl ring bonded to C containing 2 to 4 heteroatoms independently selected from N, O and S, a ring that is optionally substituted on an available carbon atom with 1 or 2 substituents selected Regardless of (1-4C) alkyl, (2-4C) alkenyl, (3-6C) cycloalkyl, amino, (1-4C) alkylamino, di (1-4C) alkylamino, (1-4C) alkylthio, (1-4C) alkoxy, (1-4C) alkoxycarbonyl, halogen, cyano and trifluoromethyl and / or in an available nitrogen atom (with the proviso that the ring does not quaternize therewith) with (1-4C) alkyl. |