abstract |
A compound of ** formula **, or a pharmaceutically acceptable salt thereof, wherein: Ring D is a 5-7 membered monocyclic ring or an 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl , said heteroaryl or heterocyclyl ring having 1-4 ring heteroatoms selected from nitrogen, oxygen or sulfur, wherein Ring D is independently substituted on any ring carbon substitutable by oxo or -R5, and on any ring nitrogen substitutable by - R4, provided that when Ring D is a 6-membered aryl or heteroaryl ring, -R5 is hydrogen at each ortho carbon position of Ring D; Rx and Ry are independently selected from T-R3, or Rx and Ry are taken together with their intermediate atoms to form a condensed, unsaturated or partially unsaturated 5-8 membered ring, which has 1-3 ring heteroatoms selected from oxygen, sulfur or nitrogen, wherein any substitutable carbon in said condensed ring is optionally and independently substituted by T-R3, and any substitutable nitrogen in said ring is substituted by R4; T is a valence bond or an alkylidene chain of 1 to 4 carbon atoms. |