http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2241680-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ddadb999be4f451dfc44d8e359d8f6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C249-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C249-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-20 |
| filingDate | 2000-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_269d1e35d524988579fa76b293a8424f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2a61fce02a5e691da6a73965f37988e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26dc55e10db1b379932238fe2e93c034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa6daea88fac0302d7df8952107b078a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b965f45007b7a35c2c819cc9c0440044 |
| publicationDate | 2005-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2241680-T3 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF CETIMINAS. |
| abstract | A process for the preparation and purification of a compound of formula (1a) comprising reacting (a) an isomeric mixture consisting of 75 to 95% of a compound of formula (2a) and 5 to 25% of a compound of formula with methylamine, in an appropriate solvent, to form an isomeric sertaline-imine mixture consisting of 75 to 95% of the formula (1a) and 5 to 25% of the formula (1b) or to react an isomeric mixture consisting of 75 to 95% of a compound of formula (2a) and 5 to 25% of a compound of formula (2b) with methylamine, in an appropriate solvent, using appropriate isolation methods to form an isomeric mixture enriched in sertralinimine, consisting of> 99 % of a compound of formula (1a) and <1% of a compound of formula (1b) (A2); and then subject the isomeric sertraline-imine mixture obtained in accordance with reaction pathway (A1) or (A2), in an appropriate solvent, to recrystallization (B), in accordance with the following scheme where in formulas (1a ), (1b), (2a) and (2b) R1, R2 and R3 are each, independently, hydrogen, halogen, trifluoromethyl or C1-C4 alkoxy, and wherein at least one of R2 and R3 is not hydrogen. |
| priorityDate | 1999-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 165.